Volume 27, Number 10, December 1999
|Page(s)||854 - 856|
Using Near-Infrared Spectroscopy for the noninvasive identification of five pharmaceutical active substances in sealed vialsM. Ulmschneider1, A. Wunenburger1 and E. Pénigault2
1 Pharmaceutical Quality Control and Assurance, F. Hoffmann - La Roche Ltd, CH-4070 Basle, Switzerland
2 Laboratoire de Photochimie Générale, UMR 7525 du CNRS, ENSCMu, 3 rue Alfred Werner, F-68093 Mulhouse Cedex, France
(Received June 16, 1999; revised December 14, 1999; accepted December 17, 1999.)
In this study, a method combining near-infrared spectroscopy and the corresponding chemometric model was developed for the noninvasive identification of five pharmaceutical active substances in sealed vials: ceftriaxone disodium salt sterile, saquinavir mesylate, saquinavir base, nelfinavir mesylate and neuraminidase inhibitor. This method is very specific, fast and nondestructive. It is an alternative to the identification performed hitherto by infrared spectroscopy. Almost no sample preparation or cleaning operation was required apart from the filling of the actives in vials. Measurements were performed on a horizontal sample desk with a monochromator NIR spectrometer.
Key words: NIR spectroscopy / pharmaceutical active substances / noninvasive identification / monochromator.
© EDP Sciences, Wiley-VCH 1999