Volume 28, Number 4, June 2000MS for the study of natural mechanisms
|Page(s)||336 - 346|
Non-invasive confirmation of the identity of tablets by near-infrared spectroscopyM. Ulmschneider1 and E. Pénigault2
1 Pharmaceutical Quality Control and Assurance, F. Hoffmann-La Roche Ltd, CH-4070 Basle, Switzerland
2 Laboratoire de Photochimie Générale, UMR 7525 du CNRS, ENSCMu, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France
(Received January 21, 2000; revised April 18, 2000; accepted April 20, 2000.)
Calibration of non-invasive near-infrared (NIR) analysis for measurements in diffuse reflectance and transmittance was conducted to confirm the identity of different film-coated and uncoated tablets. NIR-spectra of both sides of the intact tablets were recorded in diffuse reflectance. The second derivation of the spectra was computed and spectral matching was calibrated. A restricted wavelength range was proposed to recognize the tablets independently of the presentation over the NIR-light beam. For transmittance measurement, the tablets were arranged in groups according to their similarities. All calibrations were tested against an independent set of sample spectra. The NIR-method proved to be fast and effective.
Key words: Fourier transform near-infrared spectroscopy -- diffuse reflectance -- transmittance -- non-invasive tablets analysis -- identity testing.
© EDP Sciences, Wiley-VCH 2000