Free Access
Issue |
Analusis
Volume 28, Number 4, June 2000
MS for the study of natural mechanisms
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Page(s) | 336 - 346 | |
Section | Original articles | |
DOI | https://doi.org/10.1051/analusis:2000124 |
Analusis 28, 336-346 (2000)
DOI: 10.1051/analusis:2000124
1 Pharmaceutical Quality Control and Assurance, F. Hoffmann-La Roche Ltd, CH-4070 Basle, Switzerland
2 Laboratoire de Photochimie Générale, UMR 7525 du CNRS, ENSCMu, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France
(Received January 21, 2000; revised April 18, 2000; accepted April 20, 2000.)
Key words: Fourier transform near-infrared spectroscopy -- diffuse reflectance -- transmittance -- non-invasive tablets analysis -- identity testing.
© EDP Sciences, Wiley-VCH 2000
DOI: 10.1051/analusis:2000124
Non-invasive confirmation of the identity of tablets by near-infrared spectroscopy
M. Ulmschneider1 and E. Pénigault21 Pharmaceutical Quality Control and Assurance, F. Hoffmann-La Roche Ltd, CH-4070 Basle, Switzerland
2 Laboratoire de Photochimie Générale, UMR 7525 du CNRS, ENSCMu, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France
(Received January 21, 2000; revised April 18, 2000; accepted April 20, 2000.)
Abstract
Calibration of non-invasive near-infrared (NIR) analysis for measurements in
diffuse reflectance and transmittance was conducted to confirm the identity of different
film-coated and uncoated tablets. NIR-spectra of both sides of the intact tablets were
recorded in diffuse reflectance. The second derivation of the spectra was computed and
spectral matching was calibrated. A restricted wavelength range was proposed to recognize
the tablets independently of the presentation over the NIR-light beam. For transmittance
measurement, the tablets were arranged in groups according to their similarities. All
calibrations were tested against an independent set of sample spectra. The NIR-method
proved to be fast and effective.
Key words: Fourier transform near-infrared spectroscopy -- diffuse reflectance -- transmittance -- non-invasive tablets analysis -- identity testing.
© EDP Sciences, Wiley-VCH 2000