Issue |
Analusis
Volume 28, Number 1, January/February 2000
IR-Raman
|
|
---|---|---|
Page(s) | 83 - 87 | |
Section | Original articles | |
DOI | https://doi.org/10.1051/analusis:2000101 |
DOI: 10.1051/analusis:2000101
Assessing the transfer of quantitative NIR calibrations from a spectrometer to another one
M. Ulmschneider1 and E. Pénigault21 Pharmaceutical Quality Control and Assurance, F. Hoffmann - La Roche Ltd, CH-4070 Basle, Switzerland
2 Laboratoire de Photochimie Générale, UMR 7525 du CNRS, ENSCMu, 3 rue Alfred Werner, F-68093 Mulhouse Cedex, France
(Received September 21, 1999; revised January 2000; accepted February 11, 2000.)
Abstract
Many factors account for the optical differences between two near-infrared (NIR) spectrometers of the same
make and type. The use of two NIR spectrometers may involve different calibrations, that can be
transferred only with additional work, like bias adjustments, other sample measurements, model
recalculations, conversion of spectral data, etc. In most cases direct transfers of the applications are
not possible. In this study the feasibility of a calibration transfer between FOSS/NIRSystems NIR
spectrometers was checked. The set of multivariate calibrations for a non-invasive identity testing and a
direct determination of the water content in ceftriaxone disodium salt sterile (Rocephin
)
and in a preparation containing tenoxicam active substance (Tilcotil
) filled in vials, was
transferred from one spectrometer to another. Separate bias adjustments were calculated for each
calibration to fit the spectral data collected on both instruments. These considerations define a
practicable procedure to transfer quantitative NIR applications with a reasonable amount of additional
work.
Key words: NIR spectroscopy -- quantitative calibration transfer -- water content determination - multivariate calibration -- bias adjustment -- monochromator.
© EDP Sciences, Wiley-VCH 2000