Issue |
Analusis
Volume 28, Number 2, March 2000
New trends in material science
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Page(s) | 136 - 140 | |
Section | Original articles | |
DOI | https://doi.org/10.1051/analusis:2000106 |
DOI: 10.1051/analusis:2000106
Direct identification of key intermediates in containers using Fourier-transform near-infrared spectroscopy through the protective polyethylene primary packaging
M. Ulmschneider1 and E. Pénigault21 Pharmaceutical Quality Control and Assurance F. Hoffmann - La Roche Ltd, CH-4070 Basle, Switzerland
2 Laboratoire de Photochimie Générale, UMR 7525 du CNRS, ENSCMu, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France
(Received July 27, 1999; revised February 10, 2000; accepted February 22, 2000.)
Abstract
A fast and non-destructive Fourier-transform near-infrared (NIR) spectroscopy method with corresponding
chemometric calibrations was developed for the identification of key intermediates of pharmaceutical
active substances through the protective polyethylene (PE) primary packaging in containers. The samples
were measured with a laboratory spectrometer. NIR spectra of incoming containers samples were also
recorded for calibration with a spectrometer installed in the warehouse. The spectra of the different
samples were recorded by diffuse reflectance with a 2 m long glass fiber optics probe in direct contact
with the PE-protected surface of the material. The NIR spectra of the same products were stored in files
and principal component analysis combined with cluster analysis were used to refine the identification
criteria. To achieve validation of the resulting mathematical models, the samples were split into a
calibration set and a validation set. The latter was used for external and independent tests. The
resulting NIR application can be transferred to any spectrometer of the same type.
Key words: Near-IR spectroscopy -- key intermediates -- pharmaceutical active substances -- noninvasive identification -- primary packaging -- polyethylene.
© EDP Sciences, Wiley-VCH 2000