Free Access
| Issue |
Analusis
Volume 26, Number 3, April 1998
Analyse des corps gras
|
|
|---|---|---|
| Page(s) | 145 - 149 | |
| Section | Original articles | |
| DOI | https://doi.org/10.1051/analusis:1998125 | |
Analusis 26, 145-149 (1998)
DOI: 10.1051/analusis:1998125
1 Chemistry Department, Faculty of Science, UAE University, P.O. Box 17551, Al-Ain, United Arab Emirates
2 Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
Key words: Actinomycin-C1 / stripping voltammetry / hanging mercury drop electrode.
© EDP Sciences, Wiley-VCH 1998
DOI: 10.1051/analusis:1998125
Trace voltammetric measurements of cancerostatic actinomycin-C1
M.S. Ibrahim1 and Y.M. Temerk21 Chemistry Department, Faculty of Science, UAE University, P.O. Box 17551, Al-Ain, United Arab Emirates
2 Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
Abstract
Adsorptive accumulation in stripping voltammetry has been applied for trace measurements of the cancerostatic drug actinomycin-C1 (ACT). Accumulation is achieved by controlled adsorption
of ACT film on the hanging mercury drop electrode (HMDE). The cathodic stripping response was evaluated with respect to accumulation time, concentration dependence, solution conditions and
other variables. The limit of detection after 5 minutes preconcentration is 1 
g L-1 (
8 * 10-10 M). The effects of possible interferences, due to coexisting metal ions or organic substances, are
evaluated. The applicability of the method to the determination of ACT in untreated urine is described.
Key words: Actinomycin-C1 / stripping voltammetry / hanging mercury drop electrode.
© EDP Sciences, Wiley-VCH 1998