Analusis 26, 277-280 (1998)
DOI: 10.1051/analusis:1998173

Formulation of insoluble drugs. Study of pharmaceutical suspensions by response surface methodology

F. Nielloud¹, G. Marti-Mestres¹, R. Fortuné¹, J.P. Mestres² and H. Maillols<sup>1

1</sup>  Laboratoire de Technique Pharmaceutique Industrielle, Faculté de Pharmacie, Avenue C. Flahault, 34060 Montpellier Cedex, France
²  L.E.P.M.I.,Laboratoire de Chimie Analytique, Faculté de Pharmacie, Avenue C. Flahault, 34060 Montpellier Cedex, France

Abstract
The preformulation of insoluble drugs, sulfadiazine and aluminium hydroxyde, were studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called "caking", and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful to determine optimal properties is a Central Composite Design. The surfactant, thickener and electrolyte at different proportions are the 3 factors studied. This strategy allows to point on the main significant effect and to determine the concentrations of each product leading to optimal properties of the suspensions.

Key words: Preformulation / suspension / experimental design / central composite design.


© EDP Sciences, Wiley-VCH 1998