Electrochemical determination of minocycline in pharmaceutical preparations

I.G. Tanase; I.G. David; G.L. Radu; E.E. Iorgulescu; S. Litescu

doi:doi:10.1051/analusis:1998130

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Volume 26 / No 4 (May 1998)

Analusis, 26 4 (1998) 175-178

Abstract

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Issue		Analusis Volume 26, Number 4, May 1998 Proche Infrarouge PIR Pittcon 98


Page(s)		175 - 178
Section		Original articles
DOI		https://doi.org/10.1051/analusis:1998130

Analusis 26, 175-178 (1998)
DOI: 10.1051/analusis:1998130

Electrochemical determination of minocycline in pharmaceutical preparations

I.G. Tanase¹, I.G. David¹, G.L. Radu², E.E. Iorgulescu¹ and S. Litescu²

¹ Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 13, Blvd. Republicii, Bucharest, Romania
² Department of Analytical Biochemistry, National Institute for Biological Sciences, 296, Spl. Independentei, P.O. Box 17-16, 77748 Bucharest, Romania

Abstract
The possibility of electrochemical determination of minocycline on mercury and solid electrodes by various voltammetric and polarographic techniques has been undertaken. The influence of some chemical (ionic strength and pH) and instrumental parameters on the main reduction signal of minocycline was investigated. The alternating current polarographic (ACP) technique was applied to the minocycline determination either in pure form or in a commercial pharmaceutical preparation. The common excipients did not interfere. The antibiotic could be detected in the concentration range $1\ 10^{-3} - 5\ 10^{-6}$ mol L^-1. The detection limit for the quantitative determination by ACP was 1 10^-6 mol L^-1 minocycline in aqueous medium of 0.1 M NaCl. The mean recovery was 99.2% with a relative standard deviation (RSD) of 2.93% (n = 8).