Issue |
Analusis
Volume 26, Number 4, May 1998
Proche Infrarouge PIRPittcon 98 |
|
---|---|---|
Page(s) | 175 - 178 | |
Section | Original articles | |
DOI | https://doi.org/10.1051/analusis:1998130 |
DOI: 10.1051/analusis:1998130
Electrochemical determination of minocycline in pharmaceutical preparations
I.G. Tanase1, I.G. David1, G.L. Radu2, E.E. Iorgulescu1 and S. Litescu21 Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 13, Blvd. Republicii, Bucharest, Romania
2 Department of Analytical Biochemistry, National Institute for Biological Sciences, 296, Spl. Independentei, P.O. Box 17-16, 77748 Bucharest, Romania
Abstract
The possibility of electrochemical determination of minocycline on mercury and solid electrodes by various voltammetric and polarographic techniques has been undertaken. The influence of some
chemical (ionic strength and pH) and instrumental parameters on the main reduction signal of minocycline was investigated. The alternating current polarographic (ACP) technique was applied to
the minocycline determination either in pure form or in a commercial pharmaceutical preparation. The common excipients did not interfere. The antibiotic could be detected in the concentration
range
mol L-1. The detection limit for the quantitative determination by ACP was 1 10-6 mol L-1 minocycline in aqueous medium of 0.1 M NaCl. The mean recovery was 99.2%
with a relative standard deviation (RSD) of 2.93% (n = 8).
© EDP Sciences, Wiley-VCH 1998