Trace voltammetric measurements of cancerostatic actinomycin-C1M.S. Ibrahim1 and Y.M. Temerk2
1 Chemistry Department, Faculty of Science, UAE University, P.O. Box 17551, Al-Ain, United Arab Emirates
2 Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
Adsorptive accumulation in stripping voltammetry has been applied for trace measurements of the cancerostatic drug actinomycin-C1 (ACT). Accumulation is achieved by controlled adsorption of ACT film on the hanging mercury drop electrode (HMDE). The cathodic stripping response was evaluated with respect to accumulation time, concentration dependence, solution conditions and other variables. The limit of detection after 5 minutes preconcentration is 1 g L-1 ( 8 * 10-10 M). The effects of possible interferences, due to coexisting metal ions or organic substances, are evaluated. The applicability of the method to the determination of ACT in untreated urine is described.
Key words: Actinomycin-C1 / stripping voltammetry / hanging mercury drop electrode.
© EDP Sciences, Wiley-VCH 1998