Effect of pH on neohesperidin dihydrochalcone thermostability in aqueous solutionsC. Coiffard, L. Coiffard, F. Peigné and Y. De Roeck-Holtzhauer
Laboratory of Industrial Pharmacy, School of Pharmacy, 1 rue Gaston Veil, 44035 Nantes Cedex, France
The objective of this work was the evaluation of neohesperidin dihydrochalcone thermostability. For this accelerated stability study, we have used an isothermal method at three temperatures (50, 70 and 90 °C). The thermodegradation of aqueous diluted solutions of neohesperidin dihydrochalcone at various pH was studied. This degradation appeared to follow first-order kinetics and was found to be pH-dependent. In the best stability conditions (pH = 4.50), the experiments revealed an activation energy () of 45.8 kJ mol-1 and a of 164 days, at 20 °C.
Key words: Neohesperidin dihydrochalcone / thermodegradation / aqueous solutions / pH.
© EDP Sciences, Wiley-VCH 1998