A novel ion selective PVC membrane electrode for determination of propranolol in pharmaceutical formulation

H.Y. Aboul-Enein; Xian Xiang Sun

doi:doi:10.1051/analusis:2000156

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Volume 28 / No 9 (November 2000)

Analusis, 28 9 (2000) 855-858

Abstract

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Issue		Analusis Volume 28, Number 9, November 2000 Endocrine disruptors


Page(s)		855 - 858
Section		Original articles
DOI		https://doi.org/10.1051/analusis:2000156

Analusis 28, 855-858 (2000)
DOI: 10.1051/analusis:2000156

A novel ion selective PVC membrane electrode for determination of propranolol in pharmaceutical formulation

H.Y. Aboul-Enein¹ and Xian Xiang Sun²

¹ Pharmaceutical Analysis Laboratory, Biological & Medical Research Department (MBC-03), King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia
² Department of Chemical Technology, Jiangsu Institute of Petrochemical Technology, Changzhou, 213016, P.R. China

(Received September 8, 2000; revised November 28, 2000; accepted December 5, 2000.)

Abstract
A novel ion selective PVC membrane electrode for determination of propranolol is developed. Silicotungstic acid is used as the counter ion and diisononyl phthalate (DNP) used as the plastizer. The electrode exhibits excellent potential response properties, showing a Nernstian response in the concentration of $3.0 \times 10^{-6} \sim 2.6 \times 10^{-2}$ M with the slope of 54.7 mV per decade, shorter conditioning time (~ 3 h), fast response time (40 s), a lower limit of detection ( $1.0 \times 10^{-7}$ M). The electrode is successfully used for the analysis of propranolol in pharmaceutical formulation with the recoveries of 99.2 ~ 102.6%, by using a direct potentiometric method and which does not require tedious sample preparation.

Key words: Propranolol -- ion-selective electrode -- potentiometry -- analysis of drugs -- pharmaceutical analysis -- chemical sensors.

© EDP Sciences, Wiley-VCH 2000