Volume 27, Number 9, November 1999
|Page(s)||786 - 794|
Evidence for the prolongation of aspirine induced modifications in human bloodR. Curini1, G. D'Ascenzo1, A. Fraioli2, A. Gentili1, G. Girelli2, M.A. Orrù1 and S. Materazzi1
1 Dep. of Chemistry, University La Sapienza , 00185 Rome, Italy
2 Policlinico "Umberto I" , University "La Sapienza", p.le A.Moro 5, 00185 Rome, Italy
(Received February 10, 1999; revised May 07, 1999; accepted May 25, 1999.)
Aspirin is a common drug for very different purposes: it can be used for colds, for headaches, but its giving is even the usual applied therapy either for the prevention or for the pathologies of thrombosis and infarction because of the effect induced by the inhibition of thromboxane A2 synthesis. It is of relevant interest to characterize the aspirin-induced modifications in human blood to evaluate the time-dependence effects. Since the thermal analysis has been successfully applied to biological matrices to evaluate modifications and pathologies, the application of thermoanalytical techniques to the blood matrix was tempted out and the earliest results are reported: by comparing the thermoanalytical profiles of the blood samples of healthy subjects before and after aspirin giving, two different pharmacological responses can been noted and important informations about the long-term effects never reported before are proposed.
Key words: Blood -- aspirin -- modifications -- TGA -- DSC.
© EDP Sciences, Wiley-VCH 1999